The United States Congress designated Panther Den as a wilderness area in 1990. It now has a total of 1195 acres, 1081 acres is National Forest System and other portion is the Crab Orchard Wilderness. The primary trail system is the River to River Trail. This trail is well marked and has several loops are in the system. Several other trails branch off the River to River Trail and support the main trail system.
Primitive camping is allowed within designated wilderness. There is no fee for primitive camping, however visitors are limited to camping a maximum of 14 continuous days. Camp and wash 150 feet away from lakes and streams. Primitive camping is NOT allowed within designated natural areas or research natural areas (boundaries are marked with yellow posts)