My wife and I spent 4 days at Long Pine Key Campground in December.  The weather was great.  Plenty to see and do in the Everglades National Park (hiking, kayaking, cycling, bird watching, etc).  There are no water, electric or sewer hookups so be prepared.  Homestead, FL is only about 30 minutes away. It is 38 miles from Long Pine Key Campground to Flamingo, but there are many sights to see along the way.